AdSense Placement - Left, Right, Out?
Setting ads near main content may mean you lose page space for other items. Many sites have a site index or other links to the left and putting ads there may disrupt your website design. If you have site links to the left I recommend using google ads at the top. Likewise if your index is at the top you can have your ads to the left. Some use drop down links at the top which means you can place google ads at the top and to the left if you wish.
For a graphical look at ideal ad placement you can view the google heat map here:
https://www.google.com/adsense/support/bin/answer.py?answer=17954
Bear in mind what your visitor is looking for. Keep your visitors happy and they will keep coming back. Design your site for your visitor first, AdSense or other income second.
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